You can tell a lot about the crank / case seal by turning the engine over with no plug installed. Turning over slowly in the normal direction, with the throttle open, you should feel slight resistance on the downstroke, just before the transfer ports open (compression of the trapped volume in the case). Turning in reverse, you should feel slight resistance on the up stroke; after the transfer ports close (trying to expand the trapped volume in the case). If the case seal is bad, you may feel little or no resistance, and may well hear gas escaping and / or rushing in. When it gets to that stage, usually the first noticeable thing is that you can't stop the engine, either by cutting the throttle, or by choking it with a finger / thumb. It will start to hurt throttle response etc too, and ultimate performance. I've seen a few with these symptoms, but I've never personally seen an engine which wouldn't start because the crank seal was bad. Not saying it can't happen, but I think it would have to be so bad you'd notice it immediately from the above kind of methodology...