I don't run a fuel tank at the transom but I have run a few monos with the tank behind the engine in front of the radio box, including my current 45 mono. This complicates installation somewhat as the flex shaft, tuned pipe and throttle linkages run thru that area, but the engine runs fine and the boat is a lot more consistent in trim than a boat with the tank in front of the engine. This is because as the tank gets emptier and lighter the whole boat gets lighter (and wants to run looser) but the CG moves forward to compensate. With a tank in front of the engine the boats gets lighter and the CG moves back as well, both make the boat run looser.
FSRV boats carry a lot of fuel for long races and all (that I am aware of) have the radio box at the back and the fuel tank behind the engine.