I wouldn't recommend it on the booms. The weight savings isn't worth the risk. I've bent stainless screws after a good flip and also egged out the holes in the carbon fiber booms where the screw goes through them. I doubt a nylon 4-40 would hold up for very long, especially on the turn fin side.
Just think about what happens if one screw gets sheared, it goes from pulling on the boom in the corner to acting as a lever on the opposite one which could break it pretty easily.
Tapping the booms on the other hand works great, I've been doing this for years and there is NO slop in my sponsons. I get everything clamped the way I want, match drill and tap the booms for 4-40. Screw the 4-40 in until its good and tight then put a nut on the other end and tighten it like a jam nut. Rock solid.
I think you could probably get away using nylon screws on throttle/ 3rd channel servos, pipe mounts, cowl mounts, needle base mounts... etc. Just make sure to use an adequate diameter, I use 1/4-20 nylon screws to hold in the zenoah in my gas rigger and they seem to hold up ok for the most part.
Brian